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Analysis of factors that affect pseudotyping in retroviruses
(University of Missouri--Columbia, 2019)
would aid development of a safe and efficient retroviral gene therapy vector and in finding an antiviral therapeutic target. Various factors were reported to affect the glycoprotein acquisition process. Protein-protein interactions and protein...
BTrCP is required for HIV-1 Vpu modulation of CD4, GaLV Env, and BST-2/Tetherin
(University of Missouri--Columbia, 2019)
activity against BST-2/tetherin. Recently, Vpu has also been reported to interact with the clathrin adapter proteins AP-1 and AP-2, and these interactions were also found to be required for BST-2/tetherin antagonism in an S52,56 -dependent manner. In assays...
Inhibition and comprehensive analysis of hiv-1 vpu, examination of retroviral trafficking, and characterization of sars-cov-2 genetic material in wastewater
(University of Missouri--Columbia, 2021)
Both HIV-1 and SARS-CoV-2 have been responsible for millions of infectionrelated deaths. Despite advances in treatment for both viruses, neither has a cure, and those living with the disease can unknowingly spread the ...